Sulfamethoxazole susceptibility of Mycobacterium tuberculosis isolates from HIV-infected Ugandan adults with tuberculosis taking trimethoprim-sulfamethoxazole prophylaxis.

نویسندگان

  • Sam Ogwang
  • Caryn E Good
  • Brenda Okware
  • Mary Nsereko
  • Michael R Jacobs
  • W Henry Boom
  • Charles M Bark
چکیده

Additional drugs are needed for the treatment of multidrug-resistant tuberculosis (TB). Sulfamethoxazole has been shown to have in vitro activity against Mycobacterium tuberculosis; however, there is concern about resistance given the widespread use of trimethoprim-sulfamethoxazole prophylaxis among HIV-infected patients in sub-Saharan Africa. Thirty-eight of 40 Mycobacterium tuberculosis isolates (95%) from pretreatment sputum samples from Ugandan adults with pulmonary TB, including HIV-infected patients taking trimethoprim-sulfamethoxazole prophylaxis, were susceptible with MICs of ≤38.4 μg/ml.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 59 9  شماره 

صفحات  -

تاریخ انتشار 2015